The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

A new study reports that the locations where genes begin are particularly prone to mutations, and these genetic changes can ...

The first 100 bases of many genes show excess mutations, revealing a major genomic weak spot that shapes disease risk and ...

A Nobel laureate, he identified an enzyme that cuts DNA, laying the groundwork for milestones in scientific research and ...

Graying hair could be a sign that the body is effectively protecting itself from cancer, a new study suggests. Cancer-causing ...

Harvard scientists have defined the exact DNA cross-link created by colibactin, a gut microbial toxin associated with ...

A research group has demonstrated that overexpression of Cdc10-dependent transcript 1 (CDT1), a key regulator of DNA ...

A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

Tuberculosis (TB) is one of the oldest and deadliest infectious diseases we know. It commonly impacts the lungs, but can also affect other areas of the body like the spine, brain or kidneys.

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...

An investigation into cellular components in bacteria has unexpectedly uncovered a feature with relevance across many life ...